Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines
Identifieur interne : 000868 ( Main/Exploration ); précédent : 000867; suivant : 000869Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines
Auteurs : Eric A. Weaver [États-Unis] ; Michael A. Barry [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Seasonal and pandemic influenza remains a constant threat. While standard influenza vaccines have great utility, the need for improved vaccine technologies have been brought to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the most recent early and widespread influenza activity. Species C adenoviruses based on serotype 5 (AD5) are potent vehicles for gene-based vaccination. While potent, most humans are already immune to this virus. In this study, low seroprevalent species D adenoviruses Ad26, 28, and 48 were cloned and modified to express the influenza virus A/PR/8/34 hemagglutinin gene for vaccine studies. When studied
Url:
DOI: 10.1371/journal.pone.0073313
PubMed: 23991187
PubMed Central: 3749993
Affiliations:
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Weaver</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seasonal and pandemic influenza remains a constant threat. While standard influenza vaccines have great utility, the need for improved vaccine technologies have been brought to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the most recent early and widespread influenza activity. Species C adenoviruses based on serotype 5 (AD5) are potent vehicles for gene-based vaccination. While potent, most humans are already immune to this virus. In this study, low seroprevalent species D adenoviruses Ad26, 28, and 48 were cloned and modified to express the influenza virus A/PR/8/34 hemagglutinin gene for vaccine studies. When studied <italic>in vivo</italic>, these species D Ad vectors performed quite differently as compared to species C Ad vectors depending on the route of immunization. By intramuscular injection, species D vaccines were markedly weaker than species C vaccines. In contrast, the species D vaccines were equally efficient as species C when delivered mucosally by the intranasal route. Intranasal adenovirus vaccine doses as low as 10<sup>8</sup> virus particles per mouse induced complete protection against a stringent lethal challenge dose of influenza. These data support translation of species D adenoviruses as mucosal vaccines and highlight the fundamental effects of differences in virus tropism on vaccine applications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Molinari, Na" uniqKey="Molinari N">NA Molinari</name></author><author><name sortKey="Ortega Sanchez, Ir" uniqKey="Ortega Sanchez I">IR Ortega-Sanchez</name></author><author><name sortKey="Messonnier, Ml" uniqKey="Messonnier M">ML Messonnier</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Wortley, Pm" uniqKey="Wortley P">PM Wortley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name></author><author><name sortKey="Mcnally, T" uniqKey="Mcnally T">T McNally</name></author><author><name sortKey="Silverman, M" uniqKey="Silverman M">M 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Koudstaal</name></author><author><name sortKey="Verhoeven, M" uniqKey="Verhoeven M">M Verhoeven</name></author><author><name sortKey="Koel, Bf" uniqKey="Koel B">BF Koel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Weaver, Eric A" sort="Weaver, Eric A" uniqKey="Weaver E" first="Eric A." last="Weaver">Eric A. Weaver</name></region><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name><name sortKey="Barry, Michael A" sort="Barry, Michael A" uniqKey="Barry M" first="Michael A." last="Barry">Michael A. Barry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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